I don't recommend going all the way with the relic weapon upgrade.
I can craft a HQ weapon of Lv50 or Lv52 which saves you that whole ordeal and you can progress faster (there's another "relic" questline once you reach Lv60, so if you want the shinies aim for the Lv60 ones)
As an example for the bow:
Crafted Lv50 weapon is iLv 115 (Cedar Longbow)
Crafted Lv52 weapon is iLv 125 (Holy Cedar Composite Bow)
So if you're early in the progress of the Lv50 relic questline, you can grab your nearest crafter (*cough*) and let him/her make a quick HQ weapon that will last you a long while.
You can always do the questline for the shinies of course, this is just stat wise speaking of course... :3